Neuroscientist Sam Harris has two chief areas of interest: meditation and mindfulness; and global politics. In Making Sense, he explores them both with utmost candidness. He believes that getting to the truth means honestly asking hard questions and being willing to have a good faith debate, even with those whose beliefs differ vastly from our own.
Josh Clark (whom you may know from the Stuff You Should Know podcast), spends each episode talking about a different existential threat to humanity. These aren't threats that will gradually make life more difficult for more people; these threats will literally wipe out humanity if they come to pass.
Invisibilia is a podcast about the invisible forces that shape our lives - things like emotions and thoughts. They explore how these invisible forces impact us through fascinating true stories.
Reply All is a podcast about technology and how it shapes our lives. It uses humour to dive deep into topics like privacy, social media, and how tech is changing us for better and worse.
This podcast digs into important topics, and usually related to issues of health and wellness. With the high quality guests that Peter brings on, he shows how both to demonstrate how we can all do better in various areas of our lives, but also how science (particularly in health and wellness) can be done better moving forward.